Doxycycline May Prevent Aneurysms in Fistula

Doxycycline may reduce the incidence of aneurysms in haemodialysis vascular accesses
Charles Diskin, Thomas J. Stokes, Linda M. Dansby, Lautrec Radcliff and Thomas B. Carter
Auburn University, Hypertension, Nephrology, Dialysis and Transplantation, Opelika, AL, USA

Background. Doxycycline can prevent aortic aneurysms through the inhibition of enzymes that degrade vessel walls. We investigated whether haemodialysis patients who had received one or more courses of doxycycline were at less risk for aneurysms in their vascular accesses than those who had received other antibiotics.

Methods. Three hundred and eight patients undergoing chronic maintenance hemodialysis were evaluated for aneurysm formation after exposure to doxycycline or another antibiotic. Conditional forward logistical analysis using Cox proportional hazards test (SPSS) was performed to determine the potential significance of differences of aneurysm formation between the two groups.

Results. Patients who had received doxycycline appeared to be at lower risk than the control group, but the effect was most obvious in those patients with synthetic grafts.

Conclusions. Doxycycline may have the ability to reduce aneurysm formation in haemodialysis vascular accesses and a large prospective study is warranted.

Keywords: aneurysms; antibiotics; haemodialysis; medications; vascular access

Correspondence and offprint requests to: Charles Diskin, MD, HNDT, Auburn University, Bldg 21, 121 N. 20th Street, Opelika, AL 36801, USA. Email: hndtsiz@bellsouth.net
© The Author [2005]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org