When glomerulosclerosis takes place, how can we have BOTH protein leakage and toxin retention?

I mean protein leakage means that the glomeruli are very permeable while toxin retention means that they are little permeable.

I assume GFR decrease occurs due to glomerulosclerosis and the fluid cannot pass and produce the filtrate? But how protein leakage comes into play?

Any idea?


Here’s a website that discusses focal segmental glomerulosclerosis. On the right side of the page that are other links related to FSGS that might answer other questions. If this information doesn’t answer your question well enough, you might want to post your question specifically to Dr. John Agar, who is a nephrologist.