[quote=kamalshah20;11781]Thanks Gus, for your reply.
Yes, I am using Pegylated interferon. People usually get Ribavirin too but it is contraindicated in patients with renal failure because it worsens the anemia.
The side effects for me are not that bad at all. I just have mild fever on the day I take the shot and sometimes the next day. Alittle weakness maybe but nothing much more than that. But I guess its different for different people.
My Hemoglobin has fallen from 14.1 before I started the treatment to about 9.5 now (about 12 weeks after I started). My WBC count and Platelet count keep falling. I then take a shot of Neupogen (G-CSF) (about once a week) and they go up again.
My Viral Load when I first did it was about 325,000 copies/ml. I received no treatment apart from Daily nocturnal hemodialysis for about 5 months. The viral load fell to about 42,000.
At this point I started interferon and after 4 weeks of treatment the viral load was 94,000!
So, when I got no treatment, the load fell and when I started getting treatment, it actually increased! I honestly don’t know what to make of this.
I’ve just sent another sample today (at the end of 12 weeks) to check the viral load and will have to wait for about 10 days to get the results.
My doc says he is planning to add another drug - Thymosin alpha if the load does not drop.
This viral load increase is what prompted me to ask if the interferon was not acting because it was getting cleared in the dialysis sessions.[/quote]
I can remember the same happened to me, at initiation of treatment viral load rises temporarily then starts going down steadily. It was really working nice and was near clear, but like many reports on other people who used it the virus returned. Also, when the treatment is stopped its quite scary and dangerous, because the viral load elevates steadily causing liver enzymes to be quite high and that don’t mix well with dialysis. Though I still have the virus it has not caused major problems in my life. Biopsies have shown that my liver is quite well without scarring. It is reported that some people have lived quite a long life regardless they were carriers of HepC…
Anyway, I think its best to give your interferon shot after dialysis, that’s how I did it back then, BUT its better to go by what your Dr. suggests.
Good luck and I hope at the end it turns out as expected…keep us updated!
Happy New Years!